comparision of j. regia shell extract and glibenclamide on biochemical blood parameters in alloxan-induced diabetic rats

abstract juglon is the most available flavonoide in walnut green skin and its antidiabetic effects has attracted researchers in the recent years. the aim of this study is to investigation of j.regia husk hydroalcoholic extract on biochemical blood parameters in diabetic rats. in present study, 40 male rats divided in 4 groups. 1 (normal saline) was treated by saline. 2 (control) was treated by alloxan monohydrate. 3 (extract) included diabetic rats that received hydro-alcoholic extract of j.regia. 4 (glibenclamide) included diabetic rats that received glibenclamide. the results showed significant reduction of glucose– triglyceride and ldl levels in group 3 in comparison with group 2 (p<0.001). the extract also could increase hdl levels significantly compared with group 2 (p<0.001). according to the results of the present study, the extract of walnut green skin has a certain antidiabetic effect and reduces the blood glucose, lipoproteins tg, ldl, and increases the blood hdl. however to determine the exact mechanism needs to be broader studies.   keywords: j. regia hydroalcoholic extract, diabetes mellitus, glibenclamide, rat.